Pioneering mobile game can detect Alzheimer’s risk and help dementia researchers worldwide
A specially designed mobile phone game can detect people at risk of Alzheimer’s – according to new research from the University of East Anglia.
Researchers studied gaming data from an app called Sea Hero Quest, which has been downloaded and played by more than 4.3 million people worldwide.
The game, created by Deutsche Telekom in partnership with Alzheimer’s Research UK, University College London (UCL), the University of East Anglia and game developers Glitchers, has been designed to help researchers better understand dementia by seeing how the brain works in relation to spatial navigation.
As players make their way through mazes of islands and icebergs, the research team are able to translate every 0.5 seconds of gameplay into scientific data.
The team studied how people who are genetically pre-disposed to Alzheimer’s disease play the game compared to people who are not.
Published in the journal PNAS, the results show that people who are genetically at risk of developing Alzheimer’s disease can be distinguished from those who are not on specific levels of the Sea Hero Quest game.
The findings are particularly important because a standard memory and thinking test could not distinguish between the risk and non-risk groups.
Lead Researcher Prof Michael Hornberger, from UEA’s Norwich Medical School, said: “Dementia will affect 135 million people worldwide by 2050. We need to identify people earlier to reduce their risk of developing dementia in the future.
“Current diagnosis of dementia is strongly based on memory symptoms, which we know now are occurring when the disease is quite advanced. Instead, emerging evidence shows that subtle spatial navigation and awareness deficits can precede memory symptoms by many years.
“Our current findings show that we can reliably detect such subtle navigation changes in at-genetic-risk of Alzheimer’s disease healthy people without any problem symptoms or complaints. Our findings will inform future diagnostic recommendations and disease treatments to address this devastating disease.”
The data collected by the Sea Hero Quest app is vital for research because every two minutes spent playing the game is equal to five hours of lab-based research. Plus, having three million players globally equates to more than 1,700 years’ worth of lab-based research.
The team studied gaming data taken from 27,108 UK players aged between 50-75 – the most vulnerable age group to develop Alzheimer’s in the next decade.
They compared this benchmark data with a smaller lab-based group of 60 people who underwent genetic testing
In the smaller lab group, 31 volunteers carried the APOE4 gene, which is known to be linked with Alzheimer’s disease, and 29 people did not. Both lab groups were matched for age, gender, education and nationality with the benchmark cohort.
Genetic risk for Alzheimer’s is complicated. People (around one in every four) who have one copy of the APOE4 gene are around three times more likely to be affected by Alzheimer’s and develop the disease at a younger age.
Prof Hornberger said: “We found that people with a high genetic risk, the APOE4 carriers, performed worse on spatial navigation tasks. They took less efficient routes to checkpoint goals.
“This is really important because these are people with no memory problems.
“Meanwhile, those without the APOE4 gene travelled roughly the same distance as the 27,000 people forming the baseline score. This difference in performance was particularly pronounced where the space to navigate was large and open.
“It means that we can detect people who are at genetic risk of Alzheimer’s based on how they play the game.”
The team have previously reported Sea Hero Quest found people in different countries and populations navigate differently.
Hilary Evans, Chief Executive at Alzheimer’s Research UK said: “We often hear heart-breaking stories about people with dementia who get lost and can’t find their way home and we know spatial navigation difficulties like these are some of the earliest warning signs for the condition.
“Research shows us that the brain changes associated with diseases like Alzheimer’s begin decades before symptoms like memory loss start and for future Alzheimer’s treatments to be effective, it’s likely they must be given at the earliest stages of disease, before there’s too much damage to the brain.
“Using big data to help improve the early and accurate detection of the diseases that cause dementia can help revolutionise how we research and treat the condition. Sea Hero Quest is an amazing example of how pioneering research can help scientists get one step closer to a life-changing breakthrough.”
Hans-Christian Schwingen, Chief Brand Officer at Deutsche Telekom, commented: “What Sea Hero Quest has demonstrated is the unique power of innovative cross sector partnerships in advancing research. We are very proud to have been a part of facilitating such a revolutionary project and are excited to see the future insights generated through analysis of the data set collected.”
‘Big data in spatial navigation – towards personalized cognitive diagnostics of ‘at-genetic-risk’ Alzheimer’s disease’ is published in the journal PNAS.
Further information about the Sea Hero Quest initiative can be found here
A video about the game can be viewed below: